Cattle Drive Casserole is the definition of comfort food at its finest. With a base of well-seasoned ground beef simmered with tomatoes, corn, and peppers, and topped off with a golden, cheesy biscuit crust, this dish delivers on all fronts—savory, hearty, and just a touch nostalgic. Each forkful is rich and satisfying, perfect for weeknight dinners, potlucks, or lazy weekend feasts. It’s like the love child of chili and cornbread, baked into one glorious dish.

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What makes this casserole so special is its layers. The meaty filling is bold and flavorful with a slight southwestern kick, while the biscuit topping bakes up fluffy and tender on the inside, with a lightly crisp crust on top. The melted cheddar cheese adds just enough sharpness to round everything out. It’s the kind of meal you’ll want to make again and again—simple, filling, and family-approved.
Why You’ll Love This Cattle Drive Casserole
- One-dish wonder: Everything cooks together in one casserole dish, making cleanup a breeze.
- Perfect for meal prep: It reheats beautifully and is even better the next day.
- Crowd-pleaser: Ideal for feeding a family or guests—everyone loves it.
- Budget-friendly: Uses pantry staples and inexpensive ingredients.
- Customizable: Swap out veggies or cheese based on what you have on hand.
- Cozy and nostalgic: Feels like home in every bite.
Preparation Phase & Tools to Use (Essential Tools and the Importance of Each)
Before diving into this savory masterpiece, it’s helpful to gather the right equipment to make the process smooth and enjoyable. While Cattle Drive Casserole is easy to pull together, using the correct tools ensures optimal texture, flavor, and ease of preparation.
- Large Skillet: This is where the magic begins. A large, heavy-bottomed skillet allows you to brown your beef evenly and simmer your vegetables and seasonings without overcrowding.
- Mixing Bowls: Useful for combining biscuit mix and blending cheese into the topping layer.
- Casserole Dish (9×13-inch preferred): The baking vessel where all the layers come together and transform into bubbly, golden goodness.
- Wooden Spoon or Spatula: Essential for breaking up the ground beef and stirring in all the ingredients without scratching your cookware.
- Measuring Cups & Spoons: Precision matters when balancing spices and creating that perfect biscuit topping.
- Oven Mitts: Safety first! You’ll need these when pulling your piping-hot casserole from the oven.
- Whisk: Helpful for mixing the biscuit batter to a smooth consistency without overworking it.
Having these tools prepped before you start will help streamline the cooking process and guarantee a successful dish.
Preparation Tips
- Pre-chop your ingredients: Dice onions, peppers, and open all your canned goods before you start cooking to avoid mid-recipe chaos.
- Drain excess fat: After browning the beef, drain any extra grease to keep the dish balanced and not overly heavy.
- Don’t overmix biscuit batter: Mix just until combined—overmixing can lead to a dense, tough topping.
- Layer cheese thoughtfully: Add a little between layers for extra richness, but save most of it for the topping so it browns nicely.
- Let it rest before serving: Give the casserole about 5–10 minutes to cool slightly so it sets and cuts neatly.
- Use fresh herbs as garnish: A sprinkle of chopped parsley or green onion brightens the dish and adds color.
Ingredients for This Cattle Drive Casserole
Here’s everything you’ll need to bring this hearty, flavor-packed casserole to life. The ingredients are simple and easy to find, making it a perfect go-to recipe for busy nights or lazy weekends.
For the Meat & Veggie Base:
- 1 lb ground beef (80/20 or lean)
- 1 small yellow onion, diced
- 1 green bell pepper, diced
- 1 (15 oz) can diced tomatoes, undrained
- 1 (8 oz) can tomato sauce
- 1 (15 oz) can whole kernel corn, drained
- 1 (4 oz) can diced green chilies (optional for mild heat)
- 1 tsp garlic powder
- 1 tsp onion powder
- 1 tsp chili powder
- ½ tsp cumin
- Salt and black pepper to taste
For the Biscuit Topping:
- 2 cups biscuit mix (such as Bisquick)
- ⅔ cup milk
- 1 cup shredded cheddar cheese (sharp or medium)
- ½ tsp paprika (optional, for color and flavor)
Optional Garnish:
- Sour cream or Greek yogurt
- Chopped fresh parsley or green onions
This lineup delivers the perfect balance of spice, heartiness, and that golden, cheesy top layer that makes it irresistible.

Step 1: Prepare the Meat and Veggie Base
Start by heating a large skillet over medium-high heat. Add the ground beef and cook until it’s browned, breaking it apart as it cooks. Once the beef is no longer pink, drain off any excess fat.
Add the diced onion and green bell pepper to the skillet with the beef. Cook for another 4–5 minutes, or until the vegetables begin to soften.
Step 2: Build the Flavor
Stir in the diced tomatoes (with their juice), tomato sauce, drained corn, green chilies (if using), garlic powder, onion powder, chili powder, cumin, salt, and pepper. Let the mixture simmer for about 5–7 minutes until it thickens slightly and the flavors meld together.
Step 3: Transfer to the Baking Dish
Preheat your oven to 375°F (190°C). Lightly grease a 9×13-inch casserole dish. Pour the meat and veggie mixture into the dish, spreading it out evenly.
Step 4: Make the Biscuit Topping
In a mixing bowl, combine the biscuit mix and milk. Stir just until a soft dough forms—don’t overmix. Gently fold in half of the shredded cheddar cheese.
Drop spoonfuls of the biscuit dough over the meat mixture and spread it out slightly with a spatula. It doesn’t need to cover every inch—leave a few gaps for steam to escape.
Step 5: Add Cheese and Bake
Sprinkle the remaining cheddar cheese evenly over the biscuit topping. For extra flavor and color, dust lightly with paprika.
Bake uncovered for 25–30 minutes, or until the top is golden brown and a toothpick inserted into the biscuit layer comes out clean.
Step 6: Let It Rest and Serve
Remove the casserole from the oven and let it sit for about 5–10 minutes. This helps the layers settle and makes serving easier. Top with a dollop of sour cream and a sprinkle of fresh herbs if desired.
Notes
- Make it spicier: Add a dash of cayenne pepper or a few chopped jalapeños to the meat mixture if you like extra heat.
- Cheese variety: Feel free to substitute Monterey Jack, Pepper Jack, or a Mexican blend for a twist on flavor.
- Vegetarian option: Replace the ground beef with a plant-based meat alternative or a mix of black beans and lentils.
- Double it up: This recipe can easily be doubled and baked in two dishes for a larger group or for freezing.
- Biscuit from scratch?: If you don’t have biscuit mix, you can make your own with flour, baking powder, salt, and butter.
Watch Out for These Mistakes While Cooking
- Overcooking the biscuit topping: Keep an eye on the casserole in the last few minutes of baking. Overbaked biscuits can become dry and tough.
- Not draining the beef: Skipping this step can leave the dish greasy and heavy. Drain the fat for a balanced bite.
- Using watery veggies: Frozen vegetables with excess moisture can make the filling too runny. Thaw and pat them dry first.
- Uneven biscuit spreading: Don’t stress about making it perfect, but aim for relatively even coverage so the dough bakes uniformly.
- Adding cheese too early: Adding all the cheese before baking may cause it to over-brown. Save some for the last few minutes if needed.
- Forgetting to preheat the oven: Starting with a cold oven can throw off baking times and texture. Preheat to ensure a golden, puffed topping.
What to Serve With Cattle Drive Casserole?
While Cattle Drive Casserole is hearty enough to stand on its own, pairing it with the right sides and extras can take your meal to the next level.
Here Are 8 Great Recommendations:
- Simple Green Salad
A crisp salad with romaine, cherry tomatoes, cucumbers, and a tangy vinaigrette balances the richness of the casserole. - Garlic Butter Green Beans
Lightly sautéed green beans with garlic and a touch of butter bring a fresh, crunchy contrast. - Cornbread or Jalapeño Corn Muffins
Add a Southern flair with sweet or spicy cornbread for a comforting side. - Pickled Jalapeños or Red Onions
A little acidity cuts through the richness and brightens each bite. - Mexican-Style Rice
Fluffy rice with a touch of tomato and cumin works as a satisfying base or side. - Avocado Slices or Guacamole
Creamy, cool avocado balances the warm, savory filling beautifully. - Tortilla Chips and Salsa
For some added crunch and a Tex-Mex vibe, chips and a smoky salsa are a great pairing. - Fruit Salad or Fresh Pineapple Chunks
Something sweet and juicy rounds out the meal and refreshes the palate.
Storage Instructions
Cattle Drive Casserole stores exceptionally well, making it ideal for leftovers or meal prep.
- Refrigerator: Let the casserole cool completely, then cover the dish tightly with foil or transfer portions to an airtight container. It will stay fresh in the fridge for up to 4 days.
- Freezer: You can freeze the entire casserole or individual portions. Wrap tightly in foil and plastic wrap, or place in freezer-safe containers. It will keep well for up to 2 months.
- Reheating: For best results, reheat in a 350°F (175°C) oven until warmed through (15–20 minutes). Microwave individual servings in 1-minute increments until hot. Add a sprinkle of fresh cheese before reheating for an extra melty touch.
Estimated Nutrition (Per Serving – based on 6 servings)
These numbers are estimates and can vary depending on ingredient brands or substitutions:
- Calories: 430
- Protein: 24g
- Carbohydrates: 32g
- Fat: 24g
- Saturated Fat: 10g
- Unsaturated Fat: 11g
- Trans Fat: 0g
- Cholesterol: 75mg
- Sodium: 780mg
- Sugar: 6g
- Fiber: 3g
- Serving Size: 1 generous portion (~1/6th of casserole)
- Category: Casserole / Comfort Food
Frequently Asked Questions
1. Can I make Cattle Drive Casserole ahead of time?
Absolutely. You can prepare the meat mixture and biscuit topping separately, then assemble and bake when ready. It can also be fully assembled, covered, and refrigerated up to 24 hours in advance.
2. What’s a good substitute for biscuit mix?
You can use a homemade blend of 2 cups flour, 1 tbsp baking powder, ½ tsp salt, and 6 tbsp cold butter. Cut in the butter and stir in the milk as usual.
3. Can I use ground turkey instead of beef?
Yes! Ground turkey or chicken works great as a leaner alternative. Just be sure to season it well since it’s milder than beef.
4. Is this casserole spicy?
Not by default. The green chilies add mild heat, but you can omit them or use spicy additions like jalapeños or cayenne if you prefer more kick.
5. How do I keep the biscuit topping from getting soggy?
Make sure the meat mixture is slightly thickened before topping it, and bake uncovered to allow steam to escape and the biscuit to crisp.
6. Can I make this gluten-free?
Yes! Just use a gluten-free biscuit mix and double-check that all canned ingredients and spices are labeled gluten-free.
7. What cheese works best besides cheddar?
Try Pepper Jack for a spicy twist, or Monterey Jack for a mild, melty finish. A mix of cheeses works well too.
8. Can I freeze leftovers?
Definitely. Cool completely, portion into freezer-safe containers, and freeze for up to 2 months. Reheat in the oven or microwave.
Conclusion
Cattle Drive Casserole is the kind of dish that delivers comfort and flavor without requiring a culinary degree or hours in the kitchen. It’s hearty, customizable, and perfect for both casual dinners and make-ahead meals. Whether you’re feeding a family or just looking to cozy up with a warm, satisfying plate, this casserole brings rustic charm and bold flavor to your table every time.

Cattle Drive Casserole
- Total Time: 50 minutes
- Yield: 6 servings
Description
Cattle Drive Casserole is a warm, comforting, and flavor-packed dish that layers seasoned ground beef, sweet corn, tomatoes, and green chilies beneath a golden, cheesy biscuit crust. It’s a weeknight favorite and a crowd-pleaser with just enough spice and tons of rich, satisfying flavor.
Ingredients
1 lb ground beef
1 small yellow onion, diced
1 green bell pepper, diced
15 oz can diced tomatoes, undrained
8 oz can tomato sauce
15 oz can whole kernel corn, drained
4 oz can diced green chilies (optional)
1 tsp garlic powder
1 tsp onion powder
1 tsp chili powder
1/2 tsp cumin
salt and black pepper to taste
2 cups biscuit mix
2/3 cup milk
1 cup shredded cheddar cheese
1/2 tsp paprika (optional)
Instructions
1. Preheat your oven to 375°F (190°C). Lightly grease a 9×13-inch casserole dish.
2. In a large skillet, cook the ground beef over medium-high heat until browned. Drain excess fat.
3. Add the diced onion and green bell pepper to the skillet and cook for 4–5 minutes until softened.
4. Stir in the diced tomatoes, tomato sauce, corn, green chilies (if using), garlic powder, onion powder, chili powder, cumin, salt, and pepper. Simmer for 5–7 minutes to thicken.
5. Pour the beef mixture into the prepared casserole dish and spread evenly.
6. In a bowl, combine biscuit mix and milk. Stir until just combined. Fold in half of the cheddar cheese.
7. Drop spoonfuls of the biscuit dough over the beef layer. Spread gently without covering entirely.
8. Sprinkle remaining cheese on top and dust with paprika if desired.
9. Bake uncovered for 25–30 minutes or until the biscuit topping is golden and cooked through.
10. Let rest 5–10 minutes before serving. Garnish with sour cream or fresh herbs if desired.
Notes
Let the casserole cool slightly before serving to help it set and slice cleanly.
Use fresh herbs or a dollop of sour cream for a beautiful garnish.
Customize with other cheeses, veggies, or ground meat options as desired.
- Prep Time: 20 minutes
- Cook Time: 30 minutes
- Category: Casserole
- Method: Baked
- Cuisine: American
Nutrition
- Serving Size: 1 portion (1/6 of casserole)
- Calories: 430
- Sugar: 6g
- Sodium: 780mg
- Fat: 24g
- Saturated Fat: 10g
- Unsaturated Fat: 11g
- Trans Fat: 0g
- Carbohydrates: 32g
- Fiber: 3g
- Protein: 24g
- Cholesterol: 75mg
Keywords: ground beef, casserole, comfort food, biscuit topping, easy dinner